Due to impaired apoptosis of CD4+ T lymphocytes, activated self-reactive T cells cannot be cleared in a timely manner, and activated T cells cause B cells to proliferate by leaps and bounds, causing an overpowering immune response and the production of antibodies against autoantigens, which leads to the development of autoimmune diseases such as OMG [32]. This evidence concerns the gene CD4 and autoimmune disease.