A total of 12 lung cancer prognostic markers were screened: Chromobox 3 (CBX3), adenosylhomocysteinase (AHCY), Kinesin Family Member 11 (KIF11) by survival analysis based on the GEPIA public database, Mitochondrial Ribosomal Protein L12 (MRPL12), Leucine Rich Repeat Containing 59 (LRRC59), Hyaluronan Mediated Motility Receptor (HMMR), Mitochondrial Ribosomal Protein L17 (MRPL17), Transmembrane Protein 106B (TMEM106B), Trophoblast Glycoprotein (TPBG), Tubulin Gamma 1 (TUBG1), ZW10 Interacting Kinetochore Protein (ZWINT), Thyroid Hormone Receptor Interactor 13 (TRIP13). The gene discussed is CBX3; the disease is lung cancer.