SREBF2 and familial hypercholesterolemia: Since thyroid hormones are known to influence lipid homeostasis in the liver, hypothyroidism can cause hypercholesterolemia, which is commonly observed in patients with hypothyroidism (Delitala et al., 2017). Hypercholesterolemia in hypothyroidism leads to simultaneous diminishing control by triiodothyronine (T3) of SREBP-2 protein, which regulate the synthesis of cholesterol by modifying the HMG-CoA enzyme activity (Duntas and Brenta, 2018).