REN and obesity due to melanocortin 4 receptor deficiency: The predictive value of indices related to central obesity can be explained by several mechanisms, including the biological function of adipokines and cytokines, such as adiponectin, tumor necrosis factor-α, and leptin, principally in woman [51] by the stimulation of the renin-angiotensin system, considered one of the essential mechanisms in obesity-related HTN [52].