GSK3B and schizophrenia: If the PI3K/Akt pathway is dysregulated in schizophrenia patients, when DAMPs and LPS act upon TLR4s, the PI3K/Akt pathway may not be activated in the way it normally would be, and this could mean that GSK3β remains active in schizophrenia patients, resulting in a prolonged or exaggerated production of pro-inflammatory cytokines (Figure 1).