INSR and schizophrenia: Although in many schizophrenia patients, genetic dysregulation of Akt, NET, α2-adrenergic receptors or other genes could be affecting NET expression, the fact that insulin receptors can control NET via Akt phosphorylation opens up the possibility that NET dysregulation in some schizophrenia patients could be caused by aberrant insulin levels or dysfunction of the insulin receptor, leading to hyposensitivity of the insulin receptor.