Following adenosine signaling-induced activation of iPLA2 and the subsequent release of DHA from the astrocytic membrane (Strokin et al., 2003), we propose that FABP7 binds the released DHA and transports it to the nucleus, where it both activates the anti-inflammatory transcription factor PPARγ and decreases the expression of NF-κB; thus preventing the development and progression of AD. This evidence concerns the gene PPARG and Alzheimer disease.