Many studies in humans and in animal models have shown a link between the circadian clock and AD (Weldemichael and Grossberg, 2010; Cermakian et al., 2011; Musiek and Holtzman, 2016; Homolak et al., 2018; Wu et al., 2019; Lananna and Musiek, 2020; Carter et al., 2021; Fusilier et al., 2021; Nassan and Videnovic, 2022). This evidence concerns the gene CLOCK and Alzheimer disease.