We theorize that this increase in IL-6 may be mediated by PGE2 since PGE2 has been found to induce IL-6 synthesis in a human astrocytoma cell line (Fiebich et al., 1998), human synovial fibroblasts (Inoue et al., 2002), cultured astrocytes (Fiebich et al., 2001), and a murine model of inflammation (Hinson et al., 1996). The gene discussed is IL6; the disease is astrocytoma (excluding glioblastoma).