Contrary to our expectations, we found that mRNA levels of the chemokine secreted by macrophages, IL-8, were decreased in schizophrenia compared to controls overall [main effect of diagnosis: F(1,127) = 14.28, p = 2.41E-04], but that IL-8 mRNA was significantly elevated in high inflammation individuals compared to low inflammation individuals overall [main effect of inflammation: F(1,127) = 30.89, p = 1.54E-07] with no diagnosis × inflammation interaction effect [F(1,127) = 2.40, p = 0.12]. Here, CXCL8 is linked to schizophrenia.