Further, circulating macrophages can enter the brain under conditions of neuroinflammation (Minogue, 2017), and we found parenchymal and perivascular CD163+ macrophages were increased in density in the high inflammation subgroup of schizophrenia patients (Purves-Tyson et al., 2020; Weissleder et al., 2021). This evidence concerns the gene CD163 and schizophrenia.