Peripheral macrophages only enter the brain under neuroinflammatory conditions (Zhang et al., 2011, 2012), so it is important to more definitively determine the origin of the increased CD163/CD64+ macrophages in schizophrenia and to establish the phenotype of these cells in order to understand their potential consequences for brain homeostasis in patients. Here, FCGR1A is linked to schizophrenia.