In contrast, deletion of TREM2 or the adaptor tyrosine kinase-binding protein (TyroBP or DAP12), which binds to TREM2, leads to an excess of the pro-inflammatory phenotype, which decreases microglial survival and causes amyloid plaque deposition in experimental models of Alzheimer's disease (AD) (Ito and Hamerman, 2012). This evidence concerns the gene TYROBP and Alzheimer disease.