Using an ALS model of optineurin (Optn)-deficient mice, they reported that RIPK1 inhibition reduces the levels of proinflammatory cytokines, including IL-1α, IL-1β, interferon-γ (IFNγ), and TNF-α, in the spinal cord (Ito et al., 2016). This evidence concerns the gene RIPK1 and amyotrophic lateral sclerosis.