HIF1A and COVID-19: As observed in the severe vs. mild comparison, hypoxia related pathways were identified as enriched in severe COVID-19 including Hypoxia Signalling in the Cardiovascular System (z-score = 1.732; BH p-value = 4.571 × 10–02) and HIF1α Signalling (z-score = 2.109; BH p-value = 1.202 × 10–07).