Primary prevention measures need to be implemented to reduce the risk of developing BCC in dark-skinned individuals and light-skinned individuals living in countries with a warm, sunny climate; patients with phototype 1 (Celtic type, i.e., light skin, blue eyes, freckles, and red or blond hair) and, among them, patients with the altered melanocortin 1 receptor gene (MC1R, variant rs1805007). This evidence concerns the gene MC1R and skin basal cell carcinoma.