A recent review of 182 genotyped individuals having NBCCS found that individuals with PTCH1 gene mutations were more likely to be diagnosed early (p = 0.02), had mandibular keratocysts (p = 0.002), and had bifid ribs (p = 0.003) or any skeletal abnormality (p = 0.003) compared to individuals with no pathogenic variant identified [35]. Here, PTCH1 is linked to nevoid basal cell carcinoma syndrome.