ACTRT1 and hereditary disease: It is a dominant genetic disorder linked to chromosome Xq24-Xq27.1 caused by a gene mutation in the actin-related protein-testis 1 (ARP-T1/ACTRT1) gene, characterized by multiple BCCs, follicular atrophy on the back of the hands and feet (resembles the skin and is different from the palm-plantar pits of the NBCCS), hypohidrosis, and hypotrichosis [47, 48]