CD4 and cancer: Among these studied cancers, TXNIP expression has significant correlations with infiltrating levels of CD4+ T cells in 22 types of cancer, CD8+ T cells in 19 types of cancer, macrophages in 22 types of cancer, neutrophils in 25 types of cancer, and dendritic cells in 23 types of cancer (Fig. 4B–D and Additional file 3: Fig. S3, Additional file 4: Fig. S4, Additional file 5: Fig. S5 and Additional file 6: Fig. S6 all P < 0.05).