Furthermore, TXNIP expression and the levels of five MMR genes, especially MLH1, MSH2, MSH6 and PMS2, are positively correlated in KIRC, kidney renal papillary cell carcinoma (KIRP), THCA, HNSC, PRAD, pancreatic adenocarcinoma (PAAD) and pheochromocytoma and paraganglioma (PCPG) (Fig. 3G, all P < 0.01). Here, MLH1 is linked to pancreatic adenocarcinoma.