CD274 and neoplasm: Specifically, YTHDC1 elevated the biogenesis of m6A-modified circIGF2BP3, which could bind to miR-328-3p and miR-3173-5p to promote the expression of PKP3, which further increased PD-L1 abundance by enhancing PD-L1 deubiquitination mediated by OTUB1, thereby promoting tumor immune evasion.