In a recent study, decreased hepatocyte nuclear factor 3γ (HNF3γ) level was measured in HCC tissues compared with adjacent normal tissues, and it was induced by reduction of METTL14, which further facilitated sorafenib resistance by inhibiting OATP1B1 and OATP1B3 expression [73]. Here, SLCO1B1 is linked to hepatocellular carcinoma.