As such, TRIM dysregulation is a hallmark of many cancers, viral infections, developmental disorders, and neurodegenerative conditions.[15] The TRIM family member TRIM4 has recently been shown to be involved in the virus‐induced IFN production,[16] oxidative stress‐induced cell death,[17] and hepatocellular carcinoma.[18] The functional importance of TRIM4 in breast cancer, however, has yet to be established. Here, TRIM4 is linked to viral infectious disease.