To explore whether STAT3 is mechanically involved in GBM suppression of SHF, the overall STAT3 transcriptional activity was evaluated in GBM cells by a SIE reporter system used previously.[19] As shown in Figure 3A, ectopic SHF expression resulted in a significant decrease of STAT3 activity in GBM cells, persisting even under IL6 stimulation. The gene discussed is IL6; the disease is glioblastoma.