The increase of DNA fragmentation (Figure S2B, Supporting Information), cleaved Caspase‐3, and the decrease of anti‐apoptosis protein Bcl‐xL (Figure S2C, Supporting Information) was induced by SHF expression with the stress of DOX, further suggesting that SHF possess the function of promoting chemotherapy sensitivity of GBM cells. This evidence concerns the gene SHF and glioblastoma.