Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) (1, 2, 3) that is required for invasion and proliferation of ovarian cancer cells, and its activity and expression are higher in ovarian cancer cells than normal ovarian epithelial cells (4, 5, 6). This evidence concerns the gene MAP3K11 and ovarian cancer.