Interestingly, however, co-immunoprecipitation assays show that the ZNHIT3-S31L variation does not compromise the interaction of the protein with its significant binding partner, NUFIP1 (29), leaving the question of how loss-of-function of ZNHIT3 causes molecular defects in PEHO syndrome. The gene discussed is ZNHIT3; the disease is PEHO-like syndrome.