The miRNA expression patterns of the iPSC‐derived ISG15–/– macrophages revealed enrichment of the PI3K‐AKT, FoxO, and MAPK signalling pathways along with various cancer‐related pathways, whereby PI3K‐AKT and FoxO signalling pathways were most closely associated with ISG15 deficiency, as they were enriched in ISG15–/– cells both with and without IFN‐α stimulation (Figure S6D–G). This evidence concerns the gene AKT1 and cancer.