HIF1A and neoplasm: Resulting from a loss of function mutation in FH, the accumulation of fumarate has also been shown to promote epithelial‐to‐mesenchymal‐transition (EMT) by inhibiting the demethylation of an antimetastatic miRNA cluster [162], while the loss of either FH or SDH and accompanying accumulation of substrates can further promote tumour survival via hypoxia‐inducible factor 1 (HIF‐1) stabilization‐mediated angiogenesis and glycolytic adaptation [163, 164].