EGFR and neoplasm: Hydrogen peroxide in particular has been shown to oxidize and inactivate the tumour suppressor, thus removing negative regulation of the PI3K/Akt/mTOR survival pathway [59], while KRAS‐induced mitochondrial ROS generation activates epidermal growth factor receptor (EGFR) signalling via the NF‐κB transcription factor and its ligands in pancreatic acinar cells [60].