The introduction of two mutations, Atp6‐P163S and Atp6‐K90E, found in prostate and thyroid tumour samples, respectively, was shown to increase the sensitivity of yeast cells to compounds inducing oxidative stress and also delayed the activation of the yeast permeability transition pore (yPTP) upon calcium induction, which may be of importance in resistance to apoptosis [131]. The gene discussed is MT-ATP6; the disease is thyroid tumor.