The epithelial‐to‐mesenchymal transition (EMT) program converts epithelial cells to cells that entered mesenchymal cell states, expressing the classical transcription factors such Snail Family Transcriptional Repressor 1/2 (SNAI1/2), Twist Family BHLH Transcription Factor (TWIST) etc., which enables carcinoma cells to complete multi‐step process of the invasive and metastatic cascade.67, 68. This evidence concerns the gene TWIST1 and carcinoma.