APOL1 and sickle cell disease: Also, environment‐related selection gives rise to variants that are more relevant in specific groups such as African‐ancestry enriched variants related to sickle cell disease (Wonkam & de Vries, 2020), and APOL1 variants that are thought to have undergone selection rising to high frequency in sub‐Saharan Africa to protect against a deadly form of sleeping sickness, but are associated with higher risk for chronic kidney disease (Genovese et al., 2010).