Considering the different roles of PAK4 and BCAR3 on CRC cells and the multiple targets of miRNA, we decided to predict the potential target miRNAs of PAK4 and BCAR3. From the results in TargetScan and DIANA database, we surprisingly found miR-199a/b-3p could be the target miRNA of both genes. The gene discussed is PAK4; the disease is colorectal carcinoma.