TFEB and renal cell carcinoma: Similar to TFE3, TFEB is clinically relevant mainly as sporadically mutated oncogene in RCC, where it is frequently involved in a chromosomal translocation with the non-transcribed Alpha gene (MALAT1), namely t(6;11), which provides a constitutively active promoter upstream of the TFEB gene that drives its transcription [136, 140].