We also examined the temporal patients where the PAD was not an exact match in the relapse tumour compared to the primary tumour and found that the methylation classification was more stable and e.g. successfully classified two tumours (pTT-9 as supratentorial EPN, ZFTA:RELA fusion-positive, and pTT-21 as a neuroepithelial tumour with PATZ1 fusion) where the PAD could not provide a specific entity (malignant glioneural and high-grade tumour respectively). The gene discussed is PATZ1; the disease is neoplasm.