However, it could be interesting to investigate the post-surgical failure pattern of mutated KRAS adenocarcinoma also in order to personalize adjuvant locoregional treatments.In the PACIFIC study, the median PFS for the experimental arm was slightly higher than how reported in this one (16.8 vs. 15 months), mainly due to the number of local and distant failures which is higher than those reported in the pivotal study (58.3% vs. 22.5%) [19, 20]. Here, KRAS is linked to adenocarcinoma.