RHOA and colorectal carcinoma: Additionally, in the inflammation-driven colorectal cancer (CRC) cells, the activated CXCL12/CXCR4 axis results in a robust increase in lncRNA XIST, which attenuates repression of RhoA signaling by sponging miR-133a-3p, thus enhancing the cytoskeletal reorganization and invasive capacities of CRC cells [99].