In this research, human monocyte-derived cells cocultured with SKOV3 cells and/or stimulated with LPA showed adherent cell growth, an increased size, an irregular shape, pseudopodia and protrusions, and positive expression of CD163, CD206, CD14 and CD163, indicating differentiation of monocytes into CD163 + macrophages (M2-like TAMs) in the simulated serous ovarian cancer microenvironment. This evidence concerns the gene MRC1 and ovarian serous adenocarcinoma.