In a previous study, LC-MSCs reduced the number of CD4+ T cells producing IL-17 and cytotoxic CD8+ T lymphocytes (CTLs) and suppressed the expression of cytotoxic molecules (Fas ligand (FasL), perforin (PFP) and CD107) in CTLs that mediate anti-tumor immune responses [114]. Here, PRF1 is linked to neoplasm.