Furthermore, BC-MSCs recruit CXCR2+ neutrophils into TME, inducing a significant increase in expression of metastasis-related genes (CXCR4, CXCR7, MMP12, MMP13, IL-6 and TGF-β) in tumor cells and consequent metastasis [184]. The gene discussed is CXCR2; the disease is neoplasm.