MIF also induces NF-κB activation [55, 61] through interactions with CD74 and enhances NF-κB target gene expression, including cellular inhibitors of apoptosis 2 (c-IAP2), Bcl-xl, MMP-2, uridylyl phosphate adenosine (uPA) and HIF-1α, facilitating the proliferation and migration of tumor cells [62, 63]. Here, MIF is linked to neoplasm.