GPR31 and neoplasm: Collectively, these findings implied that the L1-FGGY reduces the expression of FGGY, thereby, facilitating the binding of more USP24 to GPR31 that increases GPR31 de-ubiquitination and activation of metabolic pathway for AA/12-LOX/12S-HETE and the subsequent signaling through the Wnt pathway in tumor cells for enhanced cell proliferation and invasion (Figure S9).