We further explored the three central enzymes involved in the LOX metabolic pathways, i.e. 5-LOX, 12-LOX, and 15-LOX [34] in 147 LUSC tumor samples (77 L1-FGGY+ vs. 70 L1-FGGY−) from the TJMUCH cohort (Table S20-S21). This evidence concerns the gene ALOX5 and neoplasm.