Decreased levels of the lncRNA, H19 have been reported in the skeletal muscle of diabetic human subjects and HFD fed mice and this negatively influences the insulin signaling cascade and glucose uptake (Gao et al. 2014), suggesting that the decreased levels of H19 impair skeletal muscle insulin signaling and thereby contribute to aberrant glucose metabolism in this tissue during diabetes. Here, H19 is linked to diabetes mellitus.