Patients with PCOS and obesity had significantly higher insulin resistance on OGTT as defined by HOMA-IR (4.02 vs 1.79) and lower insulin sensitivity as defined by WBISI (2.00 vs 5.13) compared to the group without obesity (p < 0.001 for both HOMA-IR and WBISI) (Fig. 2B). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.