Through the GAM and smooth curve fitting(adjusted age, sex, HGB, BMI, HCT, AST, BUN, ALB, FBG, FIB, DM, previous stroke or TIA, hypertension, CHD, stroke etiology, smoking, NIHSS score), we observed an approximate “U”-shaped relationship between the TG/HDL-c ratio and unfavorable outcomes risk in AIS patients (Fig. 4). This evidence concerns the gene CYGB and hypertensive disorder.