Besides, ALS is characterized by gradual loss of motor neurons (MNs) in the brainstem and muscle denervation atrophy in association with gliosis, induction of microglial activation along with the cytoplasmic assemblages of TAR DNA-binding protein 43 (TDP-43), and superoxide dismutase (SOD1) [38]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.