Copy-number landscape of 413 genes revealed that genes located at chromosome 7p and q, 8p and q, 13q and 20q including EGFR (07p11.2, 12.3%), MYC (08q24.21, 12.1%), FLT1 (13q12.3, 30.6%), FLT3 (13q12.2, 31.0%), SRC (20q11.23, 37.9%), AURKA (20q13.2, 36.8%), GNAS (20q13.32, 36.8%), ZNF217 (20q13.2, 43.8%) and BCL2L1 (20q11.21, 50.6%) were frequently amplified in MSS tumours (Fig. 1c). This evidence concerns the gene FLT1 and Marinesco-Sjogren syndrome.