IL18 and acute kidney injury: In Nrf2 KO mice, cisplatin-induced AKI downregulated the expression of anti-inflammatory cytokines such as Il4, Il10, and Socs1. However, pro-inflammatory cytokines including Ifng, Cxcl9, Il2, Il7, and Il18 were not upregulated in cisplatin-treated Nrf2 KO mice compared with levels in untreated Nrf2 KO mice, indicating that Nrf2-mediated regulation is more directly related to anti-inflammatory signals.