Additional qRT-PCR experiments revealed that the expressions of Plk2 and Nrf2 mRNA were markedly diminished in p53-depleted NRK52E cells with cisplatin treatment, indicating that p53 was involved in the expressions of Plk2 and Nrf2 in response to cisplatin-induced AKI (Fig. 3b). The gene discussed is NFE2L2; the disease is acute kidney injury.