The remaining ERBB2 mutations (3/18, 16.7%) were exon 20 in-frame insertions or duplications, such as p.Y772_A775dup, which are more common in non-small cell lung cancer (NSCLC) and induce a constitutively active ERBB2 protein conformation (Supplementary Table 2)33. The gene discussed is ERBB2; the disease is non-small cell lung carcinoma.