MYB and hematologic disorder: In this study, we demonstrated E2 exerted a significant therapeutic effect in different zebrafish models of MDS (c-mybhyper, pu.1G242D/G242D and irf8Δ57Δ/57), especially in the c-mybhyper MDS model, thus demonstrating that E2 may be potential therapeutic drugs for hematological diseases associated with abnormal activation of c-myb.