Moreover, LAPTM5, a lysosomal-associated multispanning membrane protein31, not only exhibited higher transcription levels in the RencaLuM2b lung derivative, but also in clinical specimens from the L-Mets and primary RCC with lung metastasis (RCCL) subgroups, compared with the pri-RCC subgroup (Supplementary Data 2). This evidence concerns the gene LAPTM5 and renal cell carcinoma.