Moreover, statistical analysis revealed a significant correlation between the staining intensity of LAPTM5 and histological grade (P = 0.039), TNM stage (P = 0.038), adverse pathological events (P = 0.002) and distant metastasis (P < 0.001) of primary RCC (Supplementary Fig. 9d and Supplementary Data 5). Here, LAPTM5 is linked to renal cell carcinoma.