LAPTM5 and neoplasm: More importantly, under the condition (1 × 105 cells) where no difference in primary tumor formation rate was observed (Fig. 8g and Supplementary Fig. 10e, f), LAPTM5 overexpression resulted in increased metastatic lesion-forming activity in the lung, and Laptm5 knockdown significantly inhibited lung metastasis (Fig. 8f, h, i).