LAPTM5 and neoplasm: We also exploited a doxycycline (Dox)-inducible (Tet-on) system to induce LAPTM5 expression in Rencaluci cells after extravasation in the lung (Supplementary Fig. 4k, l), LAPTM5 also promoted the formation of metastases in the lung in the Tet-on system (Supplementary Fig. 4l–o), suggesting that LAPTM5 may induce metastasis initiation and tumor outgrowth in the lung stromal.