Integrated analysis of these two datasets identified three genes: cathepsin S (CTSS), lysosomal protein transmembrane 5 (LAPTM5), and insulin-like growth factor binding protein 5 (IGFBP5), that appeared to be activated specifically in RCC cells from lung metastases in both datasets (Fig. 2b and Supplementary Data 2). Here, IGFBP5 is linked to renal cell carcinoma.