These data could explain the predominantly hepatic and IFNγ inducible expression of Gm4951. Long-term HFD decreased liver Gm4951 transcript expression to a level below that in livers from Gm4951Oily/+ or Gm4951Carboniferous/+ mice, which develop hepatic steatosis (Fig. 5h, i). This evidence concerns the gene IFNG and fatty liver disease.