Interestingly, numerous Ca2+-dependent transcription factors like c-FOS, nuclear factor of activated T cell (NFATC1), and cAMP response element–binding protein (CREB1) as well as the asthma-associated protein ORMDL3 were downregulated in the NCLX KD HASMCs (Fig. 4H). The gene discussed is ORMDL3; the disease is asthma.