Genes associated with active TB15,20,54 or risk of developing TB22 were substantially downregulated (GBP1, GBP2, GBP5, and IFITM3) or upregulated (GNLY and PRF1) over time in TB patients regardless of their TB treatment outcome, reflecting transcriptomic response to TB treatment (Figure 3A and Supplementary Figure S6). The gene discussed is PRF1; the disease is tuberculosis.