MMP9 and tuberculosis: Other genes associated with active TB were significantly down- or upregulated (STAT2, MMP9, IRF7, IFI6, IFIT2, IFIT3, and CCR7) during TB treatment in patients who had a good TB treatment outcome, but not in patients who had a poor TB treatment outcome, while genes such as CD3E, PTPRCv1, NLRP1, BCL2 were upregulated in patients with poor TB outcome but not in patients with good TB outcome, confirming that altered changes in patients with a poor outcome could be observed using this methodology, despite the smaller sample size.15