TLR4 and colorectal carcinoma: Cammarota et al. found that in mixed stage CRC tissue, participants with lower TLR4 expression in the tumor stroma compartment had improved DFS compared to participants with higher TLR4 expression (risk ratio (RR) 2.36; log-rank chi-square 4.25, P < 0.05) (Cammarota et al. 2010).