TLR4 and neoplasm: In contrast, Eiro and colleagues observed that recurrence was dependent on the site of TLR4 expression, not its overall quantitative expression such that TLR4 expression by tumor cells was associated with a lower rate of recurrence in tumors from left colon/rectum compared to those from right colon/rectum (P = 0.028) (Eiro et al. 2013).