This contradicts existing data, as a metanalysis of 212 people living with CRC found that high TLR4 expression associated with a significantly reduced OS and poorer prognosis (HR (95% CI) 2.30 (1.41, 3.75), P = 0.001) (Hao et al. 2018). The gene discussed is TLR4; the disease is colorectal carcinoma.