Due to CSCs pivotal role in cancer progression and recurrence, we focused our attention on CNAs differentially represented between GDC data and our isolated CSCs, identifying genes with a CN gain or loss preferentially in this subpopulation (ATE1, FGF3, KRAS, ZNF706 and CDKAL1, LRP1B, PTCH2, RAF1, TMPRSS2, TSC1, TSHZ3 respectively, Fig. 2A, B). The gene discussed is LRP1B; the disease is cancer.