For hormone‐related cancer, prostate cancer, breast cancer, digestive and colon cancer, similar negative effect was observed with increased serum Klotho levels, although the tertiles of serum Klotho was not found to be associated with breast cancer risk, but this does not affect that there was consistent with previous histological evidence that Klotho is a tumor inhibitor.28, 29, 30, 31, 32. This evidence concerns the gene KL and Familial prostate cancer.