In weighted multifactor Logistic regression, after adjusting for covariates, cancer was less likely to develop in populations with higher levels of Klotho at age 60–79 [T, OR (95CI): T2, 0.603 (0.425, 0.854); T3, 0.585 (0.415, 0.823)], in females [T, OR (95CI): T2, 0.718 (0.547,0.942); T3, 0.627 (0.485,0.811)] and in overweight people [T, OR (95CI): T2, 0.649 (0.485,0.867); T3, 0.564 (0.386,0.825)], but not in non‐Hispanic blacks (Table 2). The gene discussed is KL; the disease is cancer.