In addition, multivariate analysis showed that SDHAF2, MRPL11, COX8A, serum carbohydrate antigen 19-9 (CA19-9), tumor size and lymph node metastasis are independent factors for overall survival (OS) of ICC patients with adjuvant TACE. The gene discussed is COX8A; the disease is metastatic malignant neoplasm in the lymph nodes.