COX8A and metastatic malignant neoplasm in the lymph nodes: Further univariate and multivariate assessment of prognosis-related risk factors indicated that CA19-9 (p = 0.003), tumor size (p = 0.023), lymph node metastasis (p < 0.001), SDHAF2 expression level (p = 0.044), MRPL11 expression level (p = 0.004) and COX8A expression level (p = 0.001) were independent factors for OS of ICC patients with adjuvant TACE (Fig. 6C, Additional file 2: Table S3).