COX8A and metastatic malignant neoplasm in the lymph nodes: Since multivariate analysis suggested that CA19-9, tumor size, lymph node metastasis, SDHAF2, MRPL11 and COX8A are independent factors for OS of ICC patients with adjuvant TACE, a nomogram that included all these risk factors was constructed (C-index: 0.85, 0.81–0.89) (Fig. 6D).