CDC25B, PBX3, SEPW1 (SELENOW) and RCAN3 were supposed to participate in the pathways of cell death and survival, cancer cell proliferation, and cancer organismismal injury and abnormalities, and further drug action target gene of 5-FU, TYMS (thymidylate synthetase gene) (Fig. 1 (C), Supplementary Dataset File 6). The gene discussed is TYMS; the disease is cancer.