Herein, we newly demonstrated that 4 genes (and the proteins) as the most powerful exploratory markers for response prediction to TXT, CDDP, and 5-FU- namely, AGR2, and PDE4D for TXT; NINJ2 and possibly RAB15 for CDDP, and CDC25B for 5-FU- in hypopharyngeal cancers. This evidence concerns the gene NINJ2 and hypopharynx cancer.