The MAPT gene, encoding the microtubule associated protein tau, is central to this locus and is likely the causal gene for other neurodegenerative disorders genetically associated with the H1 haplotype, such as PSP and CBD [2, 3], given that they are characterized neuropathologically by tau hyperphosphorylation and accumulation. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.