MAPT and Alzheimer disease: In total, of all A+ individuals across the AD clinical spectrum, 94 individuals fell in subgroup 1 (p-tau ≤ 56 pg/ml), 147 individuals in subgroup 2 (p-tau 57–96 pg/ml), 89 individuals in subgroup 3 (p-tau 97–159 pg/ml), and 11 individuals in subgroup 4 (p-tau > 159 pg/ml).