MAPT and Alzheimer disease: We included a total of 453 individuals, of whom 112 were amyloid-negative CN individuals (98 controls and 14 individuals with t-tau or p-tau levels indicative of SNAP) and of whom 341 were A+ across different clinical stages (preclinical AD (n = 51), prodromal AD (n = 102), AD dementia (n = 188); full demographic characterization in Table 1).