For instance, circRNA MAT2B [25] sponged miR-338-3p to promote glycolysis and malignancy in hepatocellular carcinoma (HCC), while circPAN3 [26] mediated drug resistance in acute myeloid leukemia through binding with miR-153-5p/miR-183-5p. This evidence concerns the gene MAT2B and hepatocellular carcinoma.