ESRP1 and colorectal cancer: For instance, circCAMSAP1 in colorectal cancer can directly bind with Epithelial-splicing regulatory protein 1 (ESRP1) to promote circularization of circCAMSAP1 [10]; and QKI can induce normal linear transcripts de novo synthesis and generate circRNAs [11]; whereas, DHX9 can inhibit the formation of ALU’s complementary structures by binding to ALU elements to prevent circRNA production [12].