EGFR and methemoglobinemia: To minimize hematological and methemoglobinemia toxicity and to obtain better safety and pharmacokinetic parameters, To et al. linked the 5-indole substituent to the isoindolinone of EAI001 (2) and obtained a new EGFR allosteric compound, JBJ-02-112-05 (5), with an IC50 of 15 nmol/L for EGFR L858R/T790M [98].