NLRC4 and anemia (phenotype): Furthermore, Liang et al. (2017) reported prenatal onset of a novel mosaic heterozygous NLRC4 variant in a neonate with congenital anaemia, ascites, and a heavy oedematous placenta with fetal thrombotic vasculopathy, who subsequently developed features of hemophagocytic lymphohistiocytosis (HLH) and died at two months of age [21].